Specific targeting of Multiple Myeloma by Dual Split-signaling Chimeric Antigen Receptors T-cells directed against CD38 and CD138.

Jort J van der Schans Ziyu Wang Jennemiek van Arkel Thijs A Van Schaik Afroditi Katsarou Ruud Ruiter Thomas Baardemans Huipin Yuan Joost D de Bruijn Sonja Zweegman Niels W C J van de Donk Richard W J Groen Maria Themeli Tuna Mutis

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

We demonstrate the possibility to specifically target MM cells, even after CD38 targeted therapy, with carefully-designed dual-split CARs directed against CD38 and CD138.

Keyphrases

nk cells
multiple myeloma
induced apoptosis
stem cells
oxidative stress
mesenchymal stem cells
signaling pathway
bone marrow
cell cycle arrest