Population pharmacokinetics of clofarabine for allogeneic hematopoietic cell transplantation in paediatric patients.

A Laura NijstadStefan NierkensCaroline A LindemansJaap Jan BoelensMarc BieringsA Birgitta VersluysKim C M van der ElstAlwin D R Huitema

Published in: British journal of clinical pharmacology (2021)

A clofarabine dosing algorithm based on this PK model, using body weight and eGFR, results in a more predictable exposure than BSA-based dosing. However, the exact target exposure needs to be further investigated.

Keyphrases

body weight
end stage renal disease
ejection fraction
newly diagnosed
stem cell transplantation
intensive care unit
peritoneal dialysis
deep learning
tyrosine kinase
low dose
high dose
mass spectrometry
hematopoietic stem cell
patient reported