ACE2 Attenuates Epithelial-Mesenchymal Transition in MLE-12 Cells Induced by Silica.

Shumin Li Ya-Qian Li Hong XuZhongqiu WeiYi YangFu-Yu Jin Min Zhang Chen Wang Wenxiong Song Jingchen HuoJingyuan ZhaoXiuhong YangFang Yang

Published in: Drug design, development and therapy (2020)

The overexpression of ACE2 and treatment with DIZE can ameliorate EMT in silicotic mice via activation of the ACE2-Ang-(1-7)-Mas receptor axis, and these changes are accompanied by suppression of the ACE-Ang II-AT1 receptor axis.

Keyphrases

angiotensin ii
angiotensin converting enzyme
epithelial mesenchymal transition
induced apoptosis
signaling pathway
cell proliferation
cell cycle arrest
transcription factor
high fat diet induced
metabolic syndrome
skeletal muscle
adipose tissue
cell death
endoplasmic reticulum stress
wild type