Platelet surface receptor glycoprotein VI-dimer is overexpressed in stroke: The Glycoprotein VI in Stroke (GYPSIE) study results.

Isuru InduruwaHarriet McKinneyCarly KempsterPatrick ThomasJoana BatistaJean-Daniel MalcorArkadiusz BonnaJoanne McGeeElaine Bumanlag-AmisKarola RehnstromSophie AshfordKenji SoejimaWillem OuwehandRichard FarndaleKate DownesElizabeth WarburtonMasaaki MoroiStephanie Jung

Published in: PloS one (2022)

Stroke patients express more GPVI-dimer on their platelet surface at presentation, lasting at least until day-90 post-stroke. Small molecule GPVI-dimer inhibitors are currently in development and the results of this study validate that GPVI-dimer as an anti-thrombotic target in ischemic stroke.

Keyphrases

small molecule
atrial fibrillation