Login / Signup

Models of polymer physics for the architecture of the cell nucleus.

Andrea EspositoCarlo AnnunziatellaSimona BiancoAndrea M ChiarielloLuca FiorilloMario Nicodemi
Published in: Wiley interdisciplinary reviews. Systems biology and medicine (2018)
The depth and complexity of data now available on chromosome 3D architecture, derived by new technologies such as Hi-C, have triggered the development of models based on polymer physics to explain the observed patterns and the underlying molecular folding mechanisms. Here, we give an overview of some of the ideas and models from physics introduced to date, along with their progresses and limitations in the description of experimental data. In particular, we focus on the Strings&Binders and the Loop Extrusion model of chromatin architecture. This article is categorized under: Analytical and Computational Methods > Computational Methods.
Keyphrases
  • electronic health record
  • transcription factor
  • gene expression
  • single molecule
  • big data
  • dna damage
  • stem cells
  • optical coherence tomography
  • machine learning
  • copy number
  • mesenchymal stem cells