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Inhibition of proteasomal deubiquitinases USP14 and UCHL5 overcomes tyrosine kinase inhibitor resistance in chronic myeloid leukaemia.

Liling JiangQingyan HeXin ChenAochu LiuWa DingHaichuan ZhangXinmei ChenHuan ZhouYi MengBingyuan LiuGuanjie PengChunyan WangJinbao LiuXianping Shi
Published in: Clinical and translational medicine (2022)
Collectively, our results demonstrate targeting USP14 and UCHL5 as a potential strategy for combating TKI resistance in CML.
Keyphrases
  • chronic myeloid leukemia
  • bone marrow
  • tyrosine kinase
  • acute myeloid leukemia
  • cancer therapy
  • risk assessment
  • climate change
  • drug induced