Morphine-induced respiratory depression is independent of β-arrestin2 signalling.

Andrea KliewerAlexander GillisRob HillFrank SchmiedelChris BaileyEamonn Kelly Graeme HendersonMacdonald J ChristieStefan Schulz

Published in: British journal of pharmacology (2020)

Our findings do not support the original suggestion that β-arrestin2 signalling plays a key role in opioid-induced respiratory depression and call into question the concept of developing G protein-biased μ-opioid receptor agonists as a strategy for the development of safer opioid analgesic drugs.

Keyphrases

chronic pain
pain management
high glucose
diabetic rats
depressive symptoms
stress induced