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Efficient computation of stochastic cell-size transient dynamics.

Cesar Augusto Nieto-AcunaCesar Augusto Vargas-GarciaAbhyudai SinghJuan Manuel Pedraza
Published in: BMC bioinformatics (2019)
We approximate, up to arbitrary precision, the distribution of division times and size across time for the adder strategy in rod-shaped bacteria cells. Our approach is able to compute statistical moments like mean size and its variance from such distributions efficiently, showing close match with numerical simulations. Additionally, we observed that these distributions have periodic properties. Our approach further might shed light on the mechanisms behind gene product homeostasis.
Keyphrases
  • induced apoptosis
  • monte carlo
  • single cell
  • cell cycle arrest
  • cell therapy
  • oxidative stress
  • bone marrow
  • mesenchymal stem cells
  • dna methylation
  • brain injury
  • cell death
  • transcription factor
  • genome wide identification