Fusobacterium nucleatum-triggered neutrophil extracellular traps facilitate colorectal carcinoma progression.

Xuehua KongYu ZhangLinwei XiangYan YouYaqian DuanYuqing ZhaoShue LiRui WuJiangbo ZhangLan ZhouLiang Duan

Published in: Journal of experimental & clinical cancer research : CR (2023)

Our findings indicated that Fn-induced NETs abundance by activating TLR4-ROS and NOD1/2 signalings in neutrophils facilitated CRC progression. The combination of circulating NETs and CEA was identified as a novel screening strategy for predicting CRC occurrence and metastasis.

Keyphrases

risk assessment
toll like receptor
diabetic rats
immune response
cell death
signaling pathway
inflammatory response
dna damage
antibiotic resistance genes
drug induced
oxidative stress
wastewater treatment