Skin nerve α-synuclein deposits in Parkinson's disease and other synucleinopathies: a review.
Vincenzo DonadioPublished in: Clinical autonomic research : official journal of the Clinical Autonomic Research Society (2018)
The most suitable and commonly used technique for identifying in vivo α-syn aggregates in skin nerves is indirect immunofluorescence, although several aspects of this approach need to be standardized, particularly when synucleinopathies without autonomic failure present a patchy distribution of abnormal α-syn aggregates in skin nerves. By contrast, synucleinopathies with autonomic failure may present widespread diffusion of abnormal aggregates in autonomic skin nerves.