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Skin nerve α-synuclein deposits in Parkinson's disease and other synucleinopathies: a review.

Vincenzo Donadio
Published in: Clinical autonomic research : official journal of the Clinical Autonomic Research Society (2018)
The most suitable and commonly used technique for identifying in vivo α-syn aggregates in skin nerves is indirect immunofluorescence, although several aspects of this approach need to be standardized, particularly when synucleinopathies without autonomic failure present a patchy distribution of abnormal α-syn aggregates in skin nerves. By contrast, synucleinopathies with autonomic failure may present widespread diffusion of abnormal aggregates in autonomic skin nerves.
Keyphrases
  • soft tissue
  • heart rate variability
  • wound healing
  • heart rate
  • blood pressure
  • magnetic resonance imaging