SARS-CoV-2 infection aggravates chronic comorbidities of cardiovascular diseases and diabetes in mice.

Yuanwu MaDan LuLinlin BaoYajin QuJiangning LiuXiaolong QiLei YuXu ZhangFeifei QiQi LvYunpeng LiuXudong ShiCaixian SunJing LiJie WangYunlin HanKai GaoWei DongNing LiuShan GaoJing XueQiang WeiSidan PanHong GaoLianfeng Zhang Chuan Qin

Published in: Animal models and experimental medicine (2021)

We established mouse models mimicked the complex pathological symptoms of COVID-19 patients with chronic diseases. Pre-existing diseases could impair the inflammatory responses to SARS-CoV-2 infection, which further aggravated the pre-existing diseases. This work provided valuable information to better understand the interplay between the primary diseases and SARS-CoV-2 infection.

Keyphrases

respiratory syndrome coronavirus
cardiovascular disease
sars cov
coronavirus disease
type diabetes
mouse model
healthcare
physical activity
adipose tissue
depressive symptoms
social media
sleep quality
cardiovascular risk factors
cardiovascular events