First Synthesis of (-)-Altenuene-D3 Suitable as Internal Standard for Isotope Dilution Mass Spectrometry.
Michael A SebaldJulian GebauerThomas SommerfeldMatthias KochPublished in: Molecules (Basel, Switzerland) (2019)
Metabolites from Alternaria fungi exhibit a variety of biological properties such as phytotoxic, cytotoxic, or antimicrobial activity. Optimization of a literature procedure culminated in an efficient total synthesis of (-)-altenuene as well as a stable isotope-labeled derivative suitable for implementation in a LC-MS/MS method for mycotoxin analysis.
Keyphrases
- mass spectrometry
- gas chromatography
- liquid chromatography
- systematic review
- primary care
- tandem mass spectrometry
- high resolution mass spectrometry
- ms ms
- simultaneous determination
- liquid chromatography tandem mass spectrometry
- minimally invasive
- high resolution
- high performance liquid chromatography
- quality improvement
- pet imaging
- capillary electrophoresis
- solid phase extraction
- computed tomography
- positron emission tomography