Screening tools for predicting mortality of adults with suspected sepsis: an international sepsis cohort validation study.
Paul W BlairRittal MehtaChris Kwaku OppongSom TinEmily KoEphraim L TsalikJosh ChenowethMichelle RozoNehkonti AdamsCharmagne BeckettChristopher W WoodsDeborah A StriegelMark G SalvadorJoost BrandsmaLauren McKeanRachael E MahleWilliam R HulseySubramaniam KrishnanMichael ProutyAndrew LetiziaAnne FoxDennis FaixJames V LawlerChris DuplessisMichael G GregoryTe VanthaAlex Kwame Owusu-OforiDaniel AnsongGeorge OduroKevin L SchullyDanielle V ClarkPublished in: BMJ open (2023)
Among the cohorts, MEWS, NEWS, qSOFA and UVA scores performed better than baseline risk, largely driven by accuracy improvements in Ghana, while SIRS scores did not improve prognostication accuracy. Prognostication scores should be validated within the target population prior to clinical use.