Cataract-causing G91del mutant destabilised βA3 heteromers formation linking with structural stability and cellular viability.

βA3/βB2 heteromers play an indispensable role in maintaining lens transparency, while the βA3-G91del mutation destabilises heteromers formation with βB2-crystallin, impairs cellular viability and induces cellular apoptosis. These all might contribute to cataract development.