Combining Raman imaging and MCR-ALS analysis for monitoring retinol permeation in human skin.
Mohammed EssendoubiFatima AlsamadPhilippe NoëlMarie MeunierAmandine ScandoleraJérôme SandréMichel ManfaitCyril GobinetRomain ReynaudOlivier PiotPublished in: Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) (2021)
This study shows a proof of concept for the evaluation of retinol penetration in skin using Raman imaging coupled with MCR-ALS. This concept needs to be validated on more subjects to include inter-individual variability but also other factors affecting skin permeation (age, sex, pH, etc). Our study can be extended to other actives.