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After an initial balance favoring collagen formation and mineralization, bone turnover markers return to pre-treatment levels during long-term TNF-α inhibition in patients with ankylosing spondylitis.

Mark SideriusAnneke SpoorenbergFrans G M KroeseEveline van der VeerSuzanne Arends
Published in: PloS one (2023)
In AS patients receiving long-term TNFi, bone turnover balance favored collagen formation and facilitation of mineralization during the first 2 years of treatment. Thereafter, at 4 and 6 years of follow-up, BTM Z-scores returned to pre-treatment levels.
Keyphrases
  • ankylosing spondylitis
  • bone mineral density
  • rheumatoid arthritis
  • combination therapy
  • body composition
  • replacement therapy
  • smoking cessation