GAGE7B promotes tumor metastasis and growth via activating the p38δ/pMAPKAPK2/pHSP27 pathway in gastric cancer.

Duan-Bo ShiRan-Ran MaHui ZhangFeng HouXiang-Yu GuoPeng Gao

Published in: Journal of experimental & clinical cancer research : CR (2019)

GAGE7B may serve as a prognostic indicator in gastric cancer. GAGE7B significantly promotes gastric cancer progression by upregulating the p38δ/pMAPKAPK2/pHSP27 pathway, but it is negatively regulated by miR-30c. GAGE7B and miR-30c may be potential therapeutic targets in gastric cancer.

Keyphrases

cell proliferation
long non coding rna
signaling pathway
climate change
human health