Invasive fungal infection after heart transplantation: A 7-year, single-center experience.
Ignacio A EcheniqueMichael P AngaroneRobert A GordonJonathan RichAllen S AndersonEdwin C McGeeTravis O AbichtJoseph KangValentina StosorPublished in: Transplant infectious disease : an official journal of the Transplantation Society (2017)
The cumulative incidence was 10.7%. IFIs were associated with pre- and post-HT vancomycin-resistant Enterococcus colonization and/or infection, post-HT renal replacement therapy, anti-thymocyte globulin induction, and antibody-mediated rejection. There were no associations with diabetes mellitus, desensitization, 2R/3R cellular rejection, treatments for rejection, re-operation, neutropenia, or cytomegalovirus infection. IFIs were associated with death (P=.02, OR 3.9, 95% CI 1.3-12.1) and 1-year mortality (P<.001, OR 9.0, 95% CI 2.3-35.7), but not 3-year mortality. Associations with Hispanic ethnicity must be validated. Optimal strategies for risk reduction and prophylaxis remain undefined.