Comparative Protective Effects of N-Acetylcysteine, N-Acetyl Methionine, and N-Acetyl Glucosamine against Paracetamol and Phenacetin Therapeutic Doses-Induced Hepatotoxicity in Rats.

Tahia H SaleemNagwa Abo El-MaaliMohammed H HassanNahed A MohamedNashwa A M MostafaEmaad Abdel-KahaarAzza S Tammam

Published in: International journal of hepatology (2018)

Both PA and PH induce oxidative stress in rat liver within their therapeutic doses. NAG and NAC in pharmacological doses can antagonize the oxidative damaging effect of both PA and PH.

Keyphrases

oxidative stress
diabetic rats
drug induced
transcription factor
high glucose
ischemia reperfusion injury
endothelial cells
amino acid
endoplasmic reticulum stress
stress induced