Glia maturation factor-γ is required for initiation and maintenance of hematopoietic stem and progenitor cells.

Honghu LiQian LuoShuyang CaiRuxiu TieYe MengWei ShanYulin XuXiangjun ZengPengxu QianHe Huang

Published in: Stem cell research & therapy (2023)

We conclude that gmfg mediates blood flow-induced HSPC maintenance via regulation of YAP, and contributes to HSPC initiation through the modulation of Notch signaling. Our findings reveal a brand-new aspect of gmfg function and highlight a novel mechanism for embryonic HSPC development.

Keyphrases

blood flow
high glucose
diabetic rats
genome wide
single cell
oxidative stress
gene expression
stress induced