Metabolite variations in the sera of HIV+ patients after an oral administration of effervescent glutamine and in comparison to non-HIV individuals by NMR.
Lucas Gelain MartinsNatália FregonesiRoberto Barbosa BazotteJeane Eliete Laguila VisentainerLjubica TasicPublished in: Molecular omics (2022)
It was demonstrated that effervescent glutamine supplementation in HIV+ individuals treated with antiretroviral therapy (ART) increased CD4+ T lymphocytes, decreased inflammation biomarkers, and brought health benefits. This pilot study aimed to explore serum metabolite variations in the HIV+ group under ART after 30 days of supplementation with glutamine, and in comparison to the matched HIV- group. The group of HIV+ showed lower levels of choline, creatine, pyruvate, glutamate, lysine, and tyrosine when compared to the HIV- group. Glucose, lipids, lactate, glutamine, phenylalanine, threonine, and phenylalanine/tyrosine were higher in HIV+ patients under long ART. Serum metabolome variations were shown to be consistent with the health improvements observed in the HIV+ group after effervescent glutamine supplementation, which might aid in ART in HIV+ individuals.
Keyphrases
- antiretroviral therapy
- hiv infected
- hiv positive
- human immunodeficiency virus
- hiv aids
- hiv testing
- hiv infected patients
- hepatitis c virus
- men who have sex with men
- healthcare
- end stage renal disease
- mental health
- newly diagnosed
- public health
- magnetic resonance
- high resolution
- chronic kidney disease
- ejection fraction
- blood pressure
- risk assessment
- metabolic syndrome
- patient reported outcomes
- weight loss
- glycemic control
- health information