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Reperfused hemorrhagic myocardial infarction in rats.

Anand R NairEric A JohnsonHsin-Jung YangIvan CokicJoseph FrancisRohan Dharmakumar
Published in: PloS one (2020)
Ischemic time prior to reperfusion is a critical factor in determining whether a MI is hemorrhagic or non-hemorrhagic in rats. Specifically, a period of 90-min of ischemia prior to reperfusion can produce rat models of hemorrhagic MI, while 30-minutes of ischemia prior to reperfusion can ensure that the MIs are non-hemorrhagic. Hemorrhagic MIs in rats result in marked increase in iron deposition, proinflammatory burden and adverse left-ventricular remodeling compared to rats with non-hemorrhagic MIs.
Keyphrases
  • left ventricular
  • acute myocardial infarction
  • cerebral ischemia
  • heart failure
  • oxidative stress
  • coronary artery disease
  • aortic valve
  • left atrial