DDB2 regulates DNA replication through PCNA-independent degradation of CDT2.

Xiaojun WuMin YuZhuxia ZhangFeng LengYue MaNi XieFei Lu

Published in: Cell & bioscience (2021)

We found that CRL4DDB2 is the novel E3 ubiquitin ligases of CDT2, and DDB2 regulates DNA replication through indirectly regulates CDT1 protein stability by degrading CDT2 and promotes the assembly of pre-replication complex. Our results broaden the horizon for understanding the opposite function of CDT2 and DDB2 in tumorigenesis, and may provide clues for drug discovery in cancer therapy.

Keyphrases

drug discovery
cancer therapy
drug delivery
small molecule
binding protein
amino acid
protein protein