Type I interferon response and vascular alteration in chilblain-like lesions during the COVID-19 outbreak.

L Frumholtz Jean-David Bouaziz Maxime Battistella Jérôme Hadjadj Richard Chocron D Bengoufa Hélène Le Buanec Laura Barnabei Sonia Meynier Olivier Schwartz Ludivine Grzelak Nikaïa Smith Bruno Charbit Darragh Duffy Nader Yatim Andreea Calugareanu A Philippe Coralie L Guerin Bérangère S Joly Virginie Siguret Léa Jaume Herve Bachelez Martine Bagot Frédéric Rieux-Laucat Sarah Maylin Jérôme Le Goff Constance Delaugerre Nicolas Gendron David M Smadja Charles Cassiusnull null

Published in: The British journal of dermatology (2021)

Our findings support an activation loop in the skin in CLL associated with endothelial alteration and immune infiltration of cytotoxic and type I IFN-polarized cells leading to clinical manifestations.

Keyphrases

induced apoptosis
dendritic cells
cell cycle arrest
immune response
endothelial cells
soft tissue
cell death
oxidative stress
signaling pathway
cell proliferation
chronic lymphocytic leukemia
pi k akt
anti inflammatory