Inhibition of Protein-tyrosine Phosphatase PTP1B and LMPTP Promotes Palmitate/Oleate-challenged HepG2 Cell Survival by Reducing Lipoapoptosis, Improving Mitochondrial Dynamics and Mitigating Oxidative and Endoplasmic Reticulum Stress.
Lynda BourebabaJacek ŁyczkoMichalina AlickaNabila BourebabaAntoni SzumnyAndrzej M FalKrzysztof MaryczPublished in: Journal of clinical medicine (2020)
In conclusion, PTP's inhibitory properties may be a promising therapeutic strategy for the treatment of FFA-induced lipotoxicity in the liver and ultimately in the management of the NAFLD condition.