Specifically Sized Hyaluronan (35 kDa) Prevents Ethanol-Induced Disruption of Epithelial Tight Junctions Through a layilin-Dependent Mechanism in Caco-2 Cells.

Damien A BellosDhara SharmaMegan R McMullenJeanette WatParamananda SaikiaCarol A de la MotteLaura E Nagy

Published in: Alcoholism, clinical and experimental research (2019)

Taken together, these data indicate that HA35 interacts with layilin on intestinal epithelial cells and maintains intestinal tight junction integrity during short-term EtOH exposure.

Keyphrases

blood brain barrier
induced apoptosis
cell cycle arrest
high glucose
diabetic rats
single molecule
heat shock protein
oxidative stress
drug induced
binding protein
cell death