Exploring the Mechanism of Weikang Keli in Inhibiting Gastric Cancer through the MAPK Signaling Pathway: Based on Network Pharmacology and Experimental Verification.

Xiang ShaoYuping LiuCuihua JiangYue SunQiyang ZhangJia-Lin Gu Jie-Ge Huo Canhong Hu

Published in: Evidence-based complementary and alternative medicine : eCAM (2022)

WK showed an explicit antitumor effect on gastric cancer through the MAPK signaling pathway, and the curative effect varies in different concentrations. Besides, in model mice, the antitumor effect of high-dose WK group is close to that of platinum. This study provided a theoretical basis for the application of WK in the clinical treatment of gastric cancer.

Keyphrases

signaling pathway
pi k akt
high dose
epithelial mesenchymal transition
induced apoptosis
adipose tissue
cell proliferation
metabolic syndrome
prognostic factors