Clinical and histologic factors associated with discordance between steatosis grade derived from histology vs. MRI-PDFF in NAFLD.
Beom Kyung KimNicole BernsteinDaniel Q HuangNobuharu TamakiKento ImajoMasato YonedaNancy SutterJinho JungKhang NguyenLeyna NguyenTracy LeEgbert MadambaLisa RichardsMark A ValasekCynthia BehlingClaude B SirlinHirokazu TakahashiStephen CaldwellPublished in: Alimentary pharmacology & therapeutics (2023)
Histology overestimates steatosis grade compared to MRI-PDFF. Patients with advanced NASH are likely to be upgraded on steatosis grade by histology. These data have important implications for steatosis estimation and reporting on histology in clinical practice and trials, especially in stage 2 fibrosis patients.
Keyphrases
- insulin resistance
- high fat diet
- high fat diet induced
- magnetic resonance imaging
- clinical practice
- end stage renal disease
- ejection fraction
- contrast enhanced
- chronic kidney disease
- newly diagnosed
- adipose tissue
- metabolic syndrome
- type diabetes
- computed tomography
- patient reported outcomes
- prognostic factors
- electronic health record
- emergency department
- machine learning
- adverse drug