Vagus nerve damage increases alcohol intake and preference in a nonpreferring rat line: Relationship to vagal regulation of the hypothalamic-pituitary-adrenal axis.

Bailey N KellerAngela E SnyderCaitlin R CokerElizabeth A AguilarMary K O'BrienNicole A LookfongSarah S BingamanAmy C ArnoldAndras HajnalYuval Silberman

Published in: Alcohol, clinical & experimental research (2024)

Overall, these findings suggest that the vagus nerve may play a critical role in regulating HPA axis function via modulation of PVN CRF mRNA expression and putative PVN CRF neuronal activity. Furthermore, disruptions to vagal regulation of HPA axis function may increase alcohol intake and preference.

Keyphrases

oxidative stress
peripheral nerve
alcohol consumption
physical activity
growth hormone