PRDX6 alleviates lipopolysaccharide-induced inflammation and ferroptosis in periodontitis.

Wen-Ying Yang Xiang Meng Yue-Rong Wang Qing-Qing Wang Xin He Xiao-Yu Sun Nan Cheng Lei Zhang

Published in: Acta odontologica Scandinavica (2022)

Therefore, this study provided a new mechanistic insight that PRDX6, regulated by the NRF2 signalling, alleviates LPS-induced inflammation and ferroptosis in human gingival fibroblasts.

Keyphrases

lipopolysaccharide induced
inflammatory response
lps induced
oxidative stress
cell death
endothelial cells
mouse model