Pilot Study of High-Dose Pemetrexed in Patients with Progressive Chordoma.

Santosh Kesari Naveed Wagle Jose A Carrillo Akanksha Sharma Minhdan Nguyen Judy Truong Jaya M Gill Raffi Nersesian Natsuko Nomura Elnaz Rahbarlayegh Garni Barkhoudarian Walavan Sivakumar Daniel F Kelly Howard Krauss Matias A Bustos Dave S B Hoon Lars Anker Arun S Singh Kamalesh K Sankhala Tiffany M Juarez

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

High-dose pemetrexed appears tolerable and shows objective antitumor activity in patients with chordoma. Phase II studies of high-dose pemetrexed are warranted.

Keyphrases

high dose
small cell lung cancer
phase ii
stem cell transplantation
advanced non small cell lung cancer
low dose
clinical trial
open label
multiple sclerosis
phase iii
double blind
study protocol
placebo controlled