Long-term combination therapy with Metformin and Oxymetholone in a Fanconi Anemia mouse model.

Craig DorrellAlexander M PetersQingshuo ZhangNiveditha BalajiKevin BaradarMakiko Mochizuki-KashioAngela MajorMilton FinegoldChih-Wei LiuKun LuMarkus Grompe

Published in: bioRxiv : the preprint server for biology (2023)

mice. HSC quiescence in mutant mice was enhanced by treatment with metformin alone.Metformin treatment caused a partial normalization of gene expression in the livers of mutant mice.

Keyphrases

combination therapy
gene expression
wild type
mouse model
high fat diet induced
dna methylation
type diabetes
adipose tissue