Effects of Anticoagulants on Experimental Models of Established Chronic Liver Diseases: A Systematic Review and Meta-Analysis.

Rui Zhang Xiao-Quan Huang Yingyi Jiang Jian Wang Shi-Yao Chen

Published in: Canadian journal of gastroenterology & hepatology (2020)

Our assessments indicate that in animal models of chronic liver diseases, anticoagulants may alleviate the degree of fibrosis evaluated by the METAVIR score system, portal pressure, inflammatory activity, and serum indices of hepatocellular injury, without impacting survival. High-quality experimental studies are still required.

Keyphrases

oxidative stress
liver fibrosis