Synthesis, Characterization, and Antibacterial Activity of Ni-Substituted Krebs-type Sandwich-Tungstobismuthates Functionalized with Amino Acids.

Four new Ni-substituted Krebs-type sandwich-tungstobismuthates, K 4 Ni 2 [{Ni(β-ala)(H 2 O) 2 } 2 {Ni(H 2 O)} 2 {Ni(H 2 O)(η 2 -β-ala)} 2 ( B -β-BiW 9 O 33 ) 2 ]·49H 2 O {(β-ala) 4 (Ni 3 ) 2 (BiW 9 ) 2 } , K 3.5 Na 6.5 [{Ni(η 3 -L-asp)} 2 (WO 2 ) 2 ( B -β-BiW 9 O 33 ) 2 ]·36H 2 O·L-asp {(L-asp) 2 (NiW) 2 (BiW 9 ) 2 } , K 4 Na 6 [{Ni(gly)(H 2 O) 2 } 2 (WO 2 ) 2 ( B -β-BiW 9 O 33 ) 2 ]·86H 2 O {(gly) 2 (NiW) 2 (BiW 9 ) 2 }, and K 2 Na 8 [{Ni(η 2 -serinol) (H 2 O)} 2 {Ni(H 2 O) 2 } 2 ( B -β-BiW 9 O 33 ) 2 ]·42H 2 O {(serinol) 2 Ni 4 (BiW 9 ) 2 } have been synthesized by one-pot solution methods. All compounds have been characterized in the solid state by single-crystal X-ray diffraction (SXRD), powder X-ray diffraction (PXRD), elemental and thermogravimetric analyses, and infrared spectroscopy (IR), as well as by UV-vis spectroscopy in solution. The antibacterial activity of all compounds was studied against four bacterial strains by the determination of the minimum inhibitory concentration (MIC). The results showed that only {(β-ala) 4 (Ni 3 ) 2 (BiW 9 ) 2 } demonstrates antibacterial activity (MIC is in the range from 8 to 256 μg/mL) compared to three other Ni-Krebs sandwiches.