The Use of Anhydrous Barium Hydroxide for Selective Alkylation of Dialkyloxy- tert -butyl-calix[4]arenes.
Oleksandr A YesypenkoOleksandr O TrybratVitaly I KalchenkoPublished in: Molecules (Basel, Switzerland) (2023)
A practical method of selective alkylation of the third hydroxyl group of disubstituted tert -butyl-calix[4]arenes using anhydrous barium hydroxide as a base was developed in this study. The use of this method in the synthesis of inherently chiral derivatives is shown herein.