Peptide photowrapping of gold-silica nanocomposites for constructing MMP-responsive drug capsules for chemo-photothermal therapy.

Hao LiuSijie HeLi-Ya NiuXue-Wang GaoKe FengShumin YangJianqun ShaoWenhua ZhaoNan Xie Qing-Zheng Yang

Published in: Chemical communications (Cambridge, England) (2023)

A multifunctional undecapeptide, YYDPLGLADYY, was designed and synthesized for the photowrapping of silica-coated gold nanorods. The obtained nanocapsules, bearing a well-defined core-shell structure, were able to encapsulate a therapeutic drug, respond to an MMP-upregulated tumor microenvironment, and achieve NIR-triggered anticancer chemo-photothermal therapy with favorable efficacy.

Keyphrases

cancer therapy
photodynamic therapy
drug delivery
reduced graphene oxide
cell migration
locally advanced
fluorescence imaging
silver nanoparticles
combination therapy
drug release
emergency department
radiation therapy
drug induced
fluorescent probe
squamous cell carcinoma
adverse drug
oxide nanoparticles