Impact of afterload and infiltration on coexisting aortic stenosis and transthyretin amyloidosis.
Kush P PatelPaul Richard ScullyChristian NitscheAndreas A KammerlanderGeorge JoyGeorge ThorntonRebecca K HughesSuzanne WilliamsTherese TillinGabriella CapturLiza ChackoAndrew KelionNikant Kumar SabharwalJames D NewtonSimon KennonMick OzkorMichael MullenPhilip N HawkinsJulian D GillmoreLeon MenezesFrancesca PuglieseAlun D HughesMarianna FontanaGuy LloydThomas A TreibelJulia MascherbauerJames C MoonPublished in: Heart (British Cardiac Society) (2021)
The AS-ATTR phenotype likely reflects an early stage of amyloid infiltration, but the combined insult resembles ATTR. Even after treatment of AS, ATTR-specific therapy is therefore likely to be beneficial.
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