Low doses of fluoxetine for the treatment of emotional premenstrual syndrome: a randomized double-blind, placebo-controlled, pilot study.
Maria Clara de Morais Faleiros MaranhoVinicius Guandalini GuapoMarcos Gonçalves de RezendeCarolina Sales VieiraMarcus Lira BrandãoFrederico Guilherme GraeffThelma LovickCristina Marta Del-BenPublished in: Psychoneuroendocrinology (2023)
Low doses of fluoxetine, which may have no or few effect on the serotonergic system, but may interfere in the progesterone metabolization, seem to have some potential to mitigate emotional PMS symptoms. While the 10 mg/d of fluoxetine had the best performance on reducing emotional PMS symptoms, the 5 mg/d dose also seems to have some effect on emotional PMS symptoms. Further larger studies will help establish the lowest effective dose of flouxetine for PMS treatment.