The immune system in sporadic inclusion body myositis patients is not compromised by blood-flow restricted exercise training.
Kasper Yde JensenMikkel JacobsenHenrik Daa SchrøderPer AagaardJakob Lindberg NielsenAnders Nørkær JørgensenEleanor BoyleRune Dueholm BechSofie RosmarkLouise Pyndt DiederichsenUlrik FrandsenPublished in: Arthritis research & therapy (2019)
Low-load blood flow restriction exercise elicited an upregulation in CD3-/CD8+ expressing natural killer cell content, which suggests that 12 weeks of BFRE training evokes an amplified immune response in sIBM muscle. However, the observation of no changes in macrophage or T cell infiltration in the BFRE-trained patients indicates that patients with sIBM may engage in this type of exercise with no risk of intensified inflammatory activity.