Serum neurofilament light chain levels correlate with small fiber related parameters in patients with hereditary transthyretin amyloidosis with polyneuropathy (ATTRv-PN).

Eleonora GalosiRocco CostanzoFrancesca ForcinaStefania MorinoGiovanni AntoniniMarco SalvettiAntonio LaulettaMarco LuigettiAngela RomanoGuido PrimianoValeria GuglielminoLaura FiondaMatteo GaribaldiNicoletta EspositoPietro FalcoGiuseppe di PietroAndrea TruiniLuca Leonardi

Published in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2024)

Our study showed that sNfL reliably discriminates symptomatic ATTRv-PN patients from pre-symptomatic carriers, and found significant relations between sNfL, skin biopsy, and QST small fiber related parameters, suggesting that sNfL might be a valuable biomarker of peripheral nerve involvement in ATTRv-PN and a supportive criterion for symptomatic disease transition.

Keyphrases

peripheral nerve
end stage renal disease
newly diagnosed
ejection fraction
chronic kidney disease
prognostic factors
peritoneal dialysis
soft tissue
cerebrospinal fluid