Cessation of anti-VLA-4 therapy in a focal rat model of multiple sclerosis causes an increase in neuroinflammation.
S K VainioAlex M DickensJouni TuiskuOlli EskolaOlof SolinEliisa S LöyttyniemiDaniel Clive AnthonyJuha O RinneLaura M AirasMerja Haaparanta-SolinPublished in: EJNMMI research (2019)
These results demonstrated that cessation of anti-VLA-4 mAb treatment for 4 days caused a transient rebound increase in neuroinflammation. This highlights the usefulness of serial TSPO imaging in the fDTH-EAE model to better understand the rebound phenomenon.