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Synovial-fluid-derived microparticles express vimentin and GRP78 in their surface and exhibit an in vitro stimulatory effect on fibroblast-like synoviocytes in rheumatoid arthritis.

Benita Nancy Reni MichaelChristina Mary MariaselvamChengappa Kavadichanda GanapathyVir Singh Negi
Published in: International journal of rheumatic diseases (2023)
Microparticles express vimentin and GRP78 on their surface and stimulate synoviocytes to produce inflammatory molecules, thus sustaining local inflammation in the synovium in RA.
Keyphrases
  • rheumatoid arthritis
  • oxidative stress
  • endoplasmic reticulum stress
  • disease activity
  • ankylosing spondylitis
  • cell surface
  • interstitial lung disease