Paper spray screening and liquid chromatography/mass spectrometry confirmation for medication adherence testing: A two-step process.

Catia CostaCecile FrampasKatherine A LongmanVladimir PalitsinMahado IsmailPatrick SearsRamin NilforooshanMelanie J Bailey

Published in: Rapid communications in mass spectrometry : RCM (2019)

We have shown for the first time the sequential analysis of the same sample using paper spray and LC/MS, as well as the detection of an antipsychotic drug from a fingerprint. We propose that this workflow may also be applied to any type of sample compatible with paper spray, and will be especially convenient where only one sample is available for analysis.

Keyphrases

mass spectrometry
liquid chromatography
high resolution mass spectrometry
tandem mass spectrometry
gas chromatography
emergency department
high resolution
high performance liquid chromatography
electronic health record
loop mediated isothermal amplification
solid phase extraction