Increased Susceptibility to Pilocarpine-Induced Status Epilepticus and Reduced Latency in TRPC1/4 Double Knockout Mice.
Fang ZhengKevin D PhelanU Thaung ShwePublished in: Neurology international (2023)
Canonical transient receptor potential channels (TRPCs) are a family of calcium-permeable cation channels. Previous studies have shown that heteromeric channels comprising TRPC1 and TRPC4 mediate epileptiform bursting in lateral septal neurons and hippocampal CA1 pyramidal neurons, suggesting that TRPC1/4 channels play a pro-seizure role. In this study, we utilized electroencephalography (EEG) recording and spectral analysis to assess the role of TRPC1/4 channels in the pilocarpine model of status epilepticus (SE). We found that, surprisingly, TRPC1/4 double knockout (DKO) mice exhibited an increased susceptibility to pilocarpine-induced SE. Furthermore, SE latency was also significantly reduced in TRPC1/4 DKO mice. Further studies are needed to reveal the underlying mechanisms of our unexpected results.
Keyphrases
- vascular smooth muscle cells
- spinal cord
- high glucose
- diabetic rats
- angiotensin ii
- high fat diet induced
- heart failure
- oxidative stress
- dna methylation
- drug induced
- case control
- single cell
- magnetic resonance
- gene expression
- cerebral ischemia
- spinal cord injury
- adipose tissue
- hypertrophic cardiomyopathy
- anti inflammatory
- subarachnoid hemorrhage
- wild type
- binding protein
- data analysis