A Pilot Study Linking Endothelial Injury in Lungs and Kidneys in Chronic Obstructive Pulmonary Disease.

Francesca PolverinoMaria E Laucho-ContrerasHans PetersenVanesa BijolLynette M ShollMary E ChoiMiguel DivoVictor Pinto-PlataAlfredo ChettaYohannes TesfaigziBartolomé R CelliCaroline A Owen

Published in: American journal of respiratory and critical care medicine (2017)

Patients with COPD and/or CS-exposed mice have pulmonary and renal endothelial cell injury linked to increased endothelial cell AGEs and RAGE levels. Albuminuria could identify patients with COPD in whom angiotensin-converting enzyme inhibitor therapy improves renal and lung function by reducing endothelial injury.

Keyphrases

lung function
endothelial cells
chronic obstructive pulmonary disease
angiotensin converting enzyme
cystic fibrosis
air pollution
angiotensin ii
high glucose
type diabetes
stem cells
adipose tissue
high fat diet induced
skeletal muscle
mesenchymal stem cells
insulin resistance