Asperosaponin VI ameliorates the CMS-induced depressive-like behaviors by inducing a neuroprotective microglial phenotype in hippocampus via PPAR-γ pathway.
Xue JiangSaini YiQin LiuDapeng SuLiangyuan LiChenghong XiaoJinqiang ZhangPublished in: Journal of neuroinflammation (2022)
CMS in mice induces a pro-inflammatory microglial phenotype that causes reduced crosstalk between microglia and neuron, inflammation and synaptic dysfunction in the hippocampus, ultimately leading to depression-like behaviors. Asperosaponin VI may ameliorate the effects of CMS by inducing microglia to adopt a PPAR-γ-dependent neuroprotective phenotype.
Keyphrases
- inflammatory response
- cerebral ischemia
- neuropathic pain
- oxidative stress
- lipopolysaccharide induced
- prefrontal cortex
- lps induced
- insulin resistance
- subarachnoid hemorrhage
- depressive symptoms
- high glucose
- cognitive impairment
- mouse model
- spinal cord injury
- high fat diet induced
- brain injury
- type diabetes
- stress induced
- metabolic syndrome
- drug induced
- endothelial cells