The involvement and therapeutic potential of lncRNA Kcnq1ot1/miR-34a-5p/Sirt1 pathway in arsenic trioxide-induced cardiotoxicity.

Xiuyun ShenFengnan ZhiChunpeng ShiJincheng XuYuqiu ChaoJuan XuYunlong BaiYanan JiangBaofeng Yang

Published in: Journal of translational medicine (2023)

The lncRNA Kcnq1ot1/miR-34a-5p/Sirt1 pathway is involved in ATO-induced cardiotoxicity. Propranolol can attenuate ATO-induced cardiotoxicity at least partially through the lncRNA Kcnq1ot1/miR-34a-5p/Sirt1 pathway. Combined administration with propranolol may be a new strategy for alleviating the cardiotoxicity of ATO.

Keyphrases

high glucose
diabetic rats
oxidative stress
long non coding rna
drug induced
ischemia reperfusion injury
long noncoding rna
drinking water
risk assessment
heavy metals