Impact of Smad4 and p53 mutations on the prognosis of patients with pancreatic ductal adenocarcinoma undergoing chemotherapy.

Mamoru TakenakaMamoru TakenakaNaoshi NishidaAkane HaraYasuo OtsukaHidekazu TanakaShunsuke OmotoKosuke MinagaKentaro YamaoYasutaka ChibaKazuko SakaiKazuto NishioTomohiro WatanabeMasatoshi Kudo

Published in: International journal of clinical oncology (2023)

Tissue samples from EUS-FNB were suitable for mutational analysis. Pancreatic cancers with p53 and without Smad4 mutations responded better to chemotherapy and had a better prognosis than those others.

Keyphrases

epithelial mesenchymal transition
transforming growth factor
locally advanced
squamous cell carcinoma
chemotherapy induced
rectal cancer
radiation therapy