Amyloid-β, cortical thickness, and subsequent cognitive decline in cognitively normal oldest-old.
Wiesje PelkmansNienke LegdeurMara Ten KateFrederik BarkhofMaqsood M YaqubHenne HolstegeBart N M van BerckelPhilip ScheltensWiesje Maria van der FlierPieter Jelle VisserBetty M TijmsPublished in: Annals of clinical and translational neurology (2021)
These results show that Aβ abnormality even in the oldest old with initially normal cognition is not part of normal aging, but is associated with a decline in cognitive functioning. Other pathologies may also contribute to decline in the oldest old as cortical thickness predicted cognitive decline similarly in individuals with and without Aβ pathology.