Targeted next-generation sequencing for molecular diagnosis of endometriosis-associated ovarian cancer.

Tze-Kiong ErYu-Fa SuChun-Chieh WuChih-Chieh ChenJing WangTsung-Hua HsiehMarta Herreros-VillanuevaWan-Tzu ChenYi-Ting ChenTa-Chih LiuHung-Sheng ChenEing-Mei Tsai

Published in: Journal of molecular medicine (Berlin, Germany) (2016)

Molecular characterization of endometriosis-associated ovarian cancer genes by targeted NGS. Candidate genes predictive of malignant transformation were identified. Chromatin remodeling, PI3K-AKT-mTOR, Notch signaling, and Wnt/β-catenin pathway may promote cell malignant transformation.

Keyphrases

genome wide
cancer therapy
single cell
stem cells
gene expression
dna damage
cell proliferation
cell therapy
transcription factor
drug delivery
dna methylation
single molecule